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Another synthetic analog of ALLO, 3-ethenyl-3-hydroxy-5-pregnan-20-one (Co 3-0593), has been found to have anxiolytic effects comparable to benzodiazepines after both subcutaneous and oral administration in rodents

They are used for various photoaging and pigmentation concerns following clinical evaluation

But without long-term human data, we must be cautious

Endogenous IGF-1 is critical to human NK cell cytotoxicity Protein array data have shown IGF-1 to be preferentially produced by CD56 dim NK cells relative to CD56 bright NK cells 22 , suggesting that human NK cells have the ability to produce IGF-1

References: Vitamin C