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A., Povarnina, PYu., Logvinov, I

Author Contributions G.G., conception and design, drafting the parts of the article, figures, tables, final approval of the version to be submitted, and supervision

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

(PubMed) Molano A, Meydani SN

These studies are not designed to determine whether excess B12 intake is unhealthy