106,142 The microbial influence in systemic and cellular metabolism is a new, controversial and developing field in cancer research
Acyl-coenzyme A synthetase long-chain family (ACSL) 4 and lysophosphatidylcholine acyltransferase 3 are critical for ferroptosis because they promote the activation and incorporation of PUFAs into membrane lipids
They are exposed to extensive oxidant-induced effects, including reduced membrane integrity (and therefore motility) and damage to proteins (and therefore structure and energy production) and DNA (with fragmentation and, ultimately, reduced fertility)
In support of this idea, it has been reported that 5 mg/kg of resveratrol supplementation increases lipid peroxidation of the heart, liver, and kidney of rats [9]
With the continuous advancement of next-generation sequencing technology and the ongoing improvement of data analysis tools, we will be able to more deeply reveal the molecular mechanisms of OA and the heterogeneity among individuals