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The NAD + -salvage-pathway connection has positioned NNMT inhibition within the broader cellular-aging and sirtuin-pathway research framework, alongside NAD + precursors such as nicotinamide riboside and nicotinamide mononucleotide

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Meanwhile, changes in quality-of-life scores measured by the Short Form-36 (SF-36) physical and mental components were small and not clinically significant across groups [1]