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From 2010 to the early 2020s, PD demonstrated continued global growth, with the most rapid increases in the incidence observed in middleSDI countries, reflecting both population aging and expanded diagnostic reach [38, 51]

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Histone acetylation by histone acetyltransferases (HATs) is likely to activate transcription by relaxing chromatin and histone deacetylation by histone deacetylases (HDACs) is likely to inhibit transcription by compacting chromatin (90)