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It is highly likely that iodixanol can substitute directly for Nycodenz in any protocol if the latter solutions are isoosmotic, but as far as we know, direct comparisons between the efficacies of the two solutes have not been made

MD analysis Interatomic distances, root mean square deviations (RMSD), root mean square fluctuations, and centroids were computed using VMD1.9.4 55

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Chem Biol 15:234245 Wewer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS