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Thus, it is likely that with BPC 157 therapy, no extraosseous bone islet means the counteraction of the endochondral bone formation in extraskeletal tissues, the counteraction of vascular endothelial cells differentiation into skeletal cells, local inflammatory signals, and the release of cytokines (i.e., bone morphogenetic protein-2 and bone morphogenetic protein-4 and transforming growth factor-beta) [68]

For instance, cluster 1a in Figure 5A comprises proteins whose transcript levels are higher than those of proteins in cluster 1b

Matta et al., 2020)

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Ribas GS, Vargas CR

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