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Findings: Preclinical data showed increased collagen-related gene expression and improved tissue remodeling processes

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Concentrations of D2HG and L2HG were normalized to cell numbers

Dror and colleagues applied an epigenetic dosage index based on cumulative chromatin accessibility to classify -cells into two groups ( Although scRNA-seq and snATAC-seq datasets of pancreatic -cells have not yet been directly integrated with gut microbiome metagenomic or metabolomic profiles within a single unified study, the parallel development of these fields highlights potential points of convergence between -cell transcriptional states and microbiota-derived metabolites (Son et al., 2020)