Finally, while MR methods are indeed reliable for causal inference, it is crucial to acknowledge the necessity of further validation through a randomized controlled trial in order to enhance the credibility and robustness of the findings presented in this MR study
And don't cut corners on sourcing
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential
and D.P.-R
Diabetologia 62:18231834 Doliba NM, Rozo, AV, Roman J, Qin W, Traum D, Gao L, Liu J, Manduchi, E, Liu C, Golson ML, Vahedi G, Naji A, Matschinsky FM, Atkinson MA, Powers AC, Brissova M, Kaestner KH, Stoffers DA (2022) Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals