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Inhal Toxicol 25:91-101, 2013

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This network functions to recognize and eliminate pathogens through a series of proteolytic reactions that result in key immune processes, including opsonization of pathogens, recruitment of inflammatory cells via anaphylatoxins (e.g., C3a, C5a), and direct lysis of target cells through the formation of the membrane attack complex (MAC) ( There are three canonical pathways that are known to initiate the activation of the complement system, those are: 1