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Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron- dependent accumulation of lipid reactive oxygen species (PubMed:24439385)

However, patients using Lotiglipron exhibited increased liver enzyme levels, a possible indication of hepatic toxicity

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A significant subsequent advance was the construction of a de novo physical map (~340 Mb) using BioNano Genomics, which enabled a hybrid assembly that nearly doubled the N50 to 697 kb and greatly improved genome continuity ( In a second phase, researchers used these resources to resequence cultivated accessions of A

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