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doi: 10.1016/j.ghir.2022.101482 129 ArreseMCabreraDKalergisAMFeldsteinAE

Animal ethics statement All procedures, protocols, and medications were approved by the Johns Hopkins University Animal Care and Use Committee and were performed in accordance with the Association for Research in Vision and Ophthalmology statement for use of animals in ophthalmic and vision research, and the National Institutes of Health guide for the care and use of laboratory animals

The IGF-1 gene contains six exons that are differentially spliced to generate multiple transcript variants that result in different pre-pro-IGF-1s (Figure 2)

Tesamorelin FDA-approved for HIV-associated lipodystrophy, its used off-label to reduce abdominal fat and improve metabolic health