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Investigations comparing topical GHK-Cu with common dermatologic comparators reported indications of higher dermal procollagen, along with observations consistent with thicker and more elastic skin architecture over multi-week intervals

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This potential appears to be partially mediated through the positive action of GHK-Cu recruitment on fibroblasts, endothelial cells, and immune cells

Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src protein

Novo Nordisk filed for FDA approval of CagriSema in early 2026, with a review decision expected later this year