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There was no adverse effect on litter size, resorptions, number of dead fetuses per litter, or average weight of fetuses, but 3 out of 41 fetuses had omphaloceles

The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving blood flow, and modulation of dopamine and serotonin systems

These are the mechanisms most often cited for its cosmetic use

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Dosing is individualized based on response and side effects, often starting at lower doses than those used in transplant patients