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The binding of ammonium to TNF- activates its death domain, recruits TRADD (Tumor Necrosis factor receptor-associated death domain protein) and FADD (Fas-associating protein with a novel death domain) proteins, forms a complex, activates Caspase-8, and subsequently Caspase-3, leading to apoptosis (147)

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Barroeta I, Videla L, Carmona-Iragui M et al (2025) Current advances and unmet needs in Alzheimers disease trials for individuals with Down syndrome: navigating new therapeutic frontiers