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In contrast, tDCS significantly improves cognitive function in dementia patients, suggesting that as cognitive impairment severity increases, the efficacy of peripheral-to-central pathway interventions (e.g., aerobic exercise alone) decreases, whereas direct modulation of cortical excitability (tDCS) becomes more advantageous

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It just doesn't meaningfully reach your bloodstream

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These data confirm, as previously described in the literature [4, 5, 8, 48, 57], that sulfur dioxide is also a powerful inhibitor of laccase