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Recording of MichaelisMenten kinetics of Pt GSTF8 with flavan-3,3,4-triol ( 4 ) revealed an apparent catalytic rate constant ( k cat ) of 7.1 min 1 and a Michaelis constant ( K m ) of 147 8 M (Extended Data Fig

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For example, acyl hydrazone linkers have been used in the first generation of ADCs, such as cBR96-Dox, which demonstrated minimal premature drug release and reduced side effects in clinical trials

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Volani et al