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The anti-tumor effect of the newly developed lat1 inhibitor jph203 in colorectal carcinoma, according to a comprehensive analysis

DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

1992;180(Pt 1):137-141

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TB-500 is based on Thymosin Beta-4, a naturally occurring peptide involved in how cells move and organise particularly in studies looking at actin regulation and cell migration