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The concept of senolytics was first proposed in 2015 by James Kirklands group at the Mayo Clinic, 28 who investigated the use of a combination of dasatinib and quercetin (D + Q) to eliminate senescent cells

Nucleic Acids 30 , 198207 (2022)

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The production of rabies virus-like particles was used as a model

In clinical trials, SSRIs demonstrated response rates of 42% to 77% in patients, while Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) achieved a 48.5% remission rate in major depressive disorders, according to a study by Laux, G., Klimke, A