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Given these potential mechanisms, this study was designed to test the hypothesis that DIO mice restored to the weight and adiposity of LD controls through NNMTi treatment and LD switch 13 have a similar microbiome profile to mice continuously maintained on LD
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Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 mice
Additionally, natural small molecules such as tea polyphenols exhibit iron-chelating properties, although careful dosing is required to avoid hepatotoxicity (309)
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