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2014 (PMID 25187433), which tied the procognitive effect to HGF/c-Met dependence, was retracted in 2025 (retraction notice PMID 40312093)

Controlled clinical trials lasting 12 weeks with commercially available rhIGF-1 have shown safety and demonstrated benefits for PMS symptoms, improving social withdrawal, repetitive behaviors, hyperactivity, and sensory reactivity (147, 148) (Figure 2)

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Further, by examining hippocampal synaptosomes containing cytosolic and mitochondrial machinery during epileptogenesis, it has been observed that there is reduced ATP-linked baseline respiration of affected neurons during the acute and chronic phases of epileptogenesis