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Effects can last 1-4 weeks depending on your individual metabolism and B12 levels

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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

More than 100 published studies have evaluated the compound in in-vitro and animal model systems, including gastrointestinal cytoprotection models, tendon and ligament tissue research, and neurological signaling pathway investigations