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Without adequate hydration, mobilised toxins can remain in circulation longer, increasing the likelihood of headaches and fatigue

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Weeks Tirzepatide dose Notes 14 2.5 mg Initiation only (not for glucose/weight effect) 58 5 mg First maintenance option 912 7.5 mg Increase as tolerated 1316 10 mg Maintenance option 1720 12.5 mg Increase as tolerated 21+ 15 mg (max) Maximum maintenance dose These steps follow the Mounjaro FDA label and Zepbound FDA label

However, adaptive mechanismsAR amplification, gain-of-function mutations, splice variant generation (e.g., AR-V7), and downstream signaling rewiringculminate in CRPC (Formaggio et al., 2021

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