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Peptide analogs and biomaterial based strategies such as self-assembling peptide hydrogels and biomimetic compounds remain in earlier developmental phases, with preclinical research indicating capacity for disc regeneration, stem cell preservation, and improved disc structure and mechanics, though clinical application awaits validation and long term safety assessment [4041]

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Gordon AC, Mason AJ, Thirunavukkarasu N, Perkins GD, Cecconi M, Cepkova M, et al

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