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Approximately 95% of the oxygen consumed is reduced to water during aerobic metabolism, but the remaining fraction may be converted to reactive oxygen species and other free radicals, inducing oxidative stress

Savolitinib is a novel and highly selective c-Met inhibitor, which has shown encouraging results in the phase III randomized clinical trial of papillary renal cell carcinoma (PRCC) ( Tivantinib, foretinib, and other c-Met tyrosine kinase inhibitors (TKIs), have previously resulted in no clear antitumor activity in gastric cancer patients (Shah et al., 2013

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Finally, the sample size was very small

61 Additionally, the role of neuromuscular control in ACL injury prevention cannot be overlooked