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Copper complexation appears to facilitate rather than inhibit CNS penetration based on animal pharmacokinetic studies

There are still many problems such as the complexity of advanced drug delivery systems, especially for lipid-based nanocarriers, and the concerns of safety of the substance incorporated in these systems (225)

The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions (1)