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The water extract of Lycium barbarum (LB), administered at doses of 0.5 g/kg and 2.0 g/kg for 4 weeks, significantly improved behavioral and cognitive performance in BALB/c mice

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Safety and Side Effects The safety profile of thymosin beta-4 is generally favorable in published preclinical studies

its intervention significantly increased the abundance of beneficial bacteria like Akkermansia muciniphila and regulated the host bile acid pool, indicating that specific gut microbes mediated the alleviation effect of obeticholic acid by regulating host bile acid metabolism

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